反应详情

To a solution of 4-methoxy-benzenesulfonyl chloride (1.0 g, 4.8 mmol) in acetonitrile (20 mL) was added KF (563 mg, 9.7 mmol) and the resulting mixture was stirred for 16 h at room temperature. The solid was filtered off and the filtrate was concentrated in vacuo. The residue was dissolved in EtOAc and washed with water. The organic phase was dried (MgSO4) and concentrated in vacuo to give the title compound (780 mg) as a colourless oil. 1H NMR (CDCl3): 7.97 (2H, d), 7.09 (2H, d), 3.94 (3H, s).

1. filtrationThe solid was filtered off
2. concentrationthe filtrate was concentrated in vacuo
3. dissolutionThe residue was dissolved in EtOAc
4. washwashed with water
5. dry with materialThe organic phase was dried (MgSO4)
6. concentrationconcentrated in vacuo