Chlorosulfonic acid → HCID 86723952, compound

HRID 1475332Notes

Reaction equation

HRID 1475332 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11](=[O:13])[CH3:12])[CH2:6][C:5]2([CH3:15])[CH3:14].[Cl:16][S:17](O)(=[O:19])=[O:18]>>[C:11]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[C:10]([S:17]([Cl:16])(=[O:19])=[O:18])[CH:9]=2)[C:5]([CH3:15])([CH3:14])[CH2:6]1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 210822421-acetyl-5-fluoro-2,3-dihydro-3,3-dimethyl-1H-Indole

Product 1

HCID 86723952HCID 86723952, compound

Procedure

1-(5-Fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-ethanone (1.1 g, 6.0 mmol) was treated with chlorosulfonic acid (10 mL) following similar methods to those described in Preparation 63) to give the desired compound (900 mg) as a grey solid. 1H NMR (Acetone-d6): 8.76 (1H, d), 7.54 (1H, d), 4.10 (2H, s), 2.32-2.23 (3H, m), 1.48 (6H, s).

Workup

  1. customthose described in Preparation 63)

Sources & evidence

ORD record
ord-e3c86c5c821645e88305b59699015ef3
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

Loading…