Hydrochloric Acid → HCID 86723953, compound

HRID 1475334Notes

Reaction equation

HRID 1475334 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[S:11]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(=[O:13])=[O:12])[N:7](C(=O)C)[CH2:6][C:5]2([CH3:23])[CH3:22].Cl>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[S:11]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(=[O:12])=[O:13])[NH:7][CH2:6][C:5]2([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70980513HCID 70980513, compound

Product 1

HCID 86723953HCID 86723953, compoundYield 57.9%

Procedure

The title compound was prepared by treating 1-[5-Fluoro-3,3-dimethyl-6-(pyrrolidine-1-sulfonyl)-2,3-dihydro-indol-1-yl]-ethanone (287 mg, 0.84 mmol) with hydrochloric acid (5 M, 1.7 mL) following similar methods to those described in Preparation 66 to give the title compound (145 mg) as a light brown oil. 1H NMR (DMSO-d6): 7.13 (1H, d), 6.79 (1H, d), 5.79 (1H, d), 3.25 (2H, s), 3.23-3.11 (4H, m), 1.83-1.68 (4H, m), 1.25 (6H, s).

Workup

  1. customThe title compound was prepared
  2. customthose described in Preparation 66

Sources & evidence

ORD record
ord-319a6f33d08448408f9b6f095a40c4f6
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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