Hydrochloric Acid → HCID 86723954, compound

HRID 1475336Notes

Reaction equation

HRID 1475336 reaction equation
[CH2:1]([S:3]([C:6]1[CH:14]=[C:13]2[C:9]([C:10]([CH3:19])([CH3:18])[CH2:11][N:12]2C(=O)C)=[CH:8][C:7]=1[F:20])(=[O:5])=[O:4])[CH3:2].Cl>>[CH2:1]([S:3]([C:6]1[CH:14]=[C:13]2[C:9]([C:10]([CH3:19])([CH3:18])[CH2:11][NH:12]2)=[CH:8][C:7]=1[F:20])(=[O:5])=[O:4])[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70980708HCID 70980708, compound

Product 1

HCID 86723954HCID 86723954, compoundYield 58.7%

Procedure

1-(6-Ethanesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-ethanone (160 mg, 0.53 mmol) was treated with hydrochloric acid (5 M, 1.1 mL) following similar methods to those described in Preparation 66 to give the title compound (80 mg). MS: [M+H]+ 258.

Workup

  1. customthose described in Preparation 66

Sources & evidence

ORD record
ord-6f06b94f103445aaa94b5397235bd943
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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