2-Chloropyridin-4-amine → 2-Chloro-5-iodopyridin-4-amine

N-Iodosuccinimide (24.75 g, 110.0 mmol) was added to a solution of 2-chloro-pyridin-4-ylamine (12.85 g, 100.0 mmol) in acetonitrile (400 mL) and the mixture stirred and held at reflux overnight. Upon cooling to room temperature the solvent was removed in vacuo and residue partitioned between EtOAc (250 mL), saturated sodium thiosulfate (100 mL) and water (250 mL). The organic layer was separated, washed with water (2×250 mL), separated and the solvent removed in vacuo to afford an orange oil that was subjected to column chromatography on silica. Gradient elution with 30-50% EtOAc in petrol afforded a pale orange solid that was rinsed with 25% EtOAc in petrol (80 mL). Solids were collected by filtration and sucked dry to afford the title compound (7.32 g) as an off-white solid. The mother liquors were concentrated to dryness in vacuo and the residues subjected to column chromatography on silica. Elution with 30-50% EtOAc in petrol afforded further pure material (1.90 g). Combined yield: (9.22 g, 36%) 1H NMR (DMSO-d6) 8.20 (1H, s), 6.64 (1H, s), 6.50 (2H, br s). MS: [M+H]+ 255.

1. temperatureat reflux overnight
2. customwas removed in vacuo and residue
3. custompartitioned between EtOAc (250 mL), saturated sodium thiosulfate (100 mL) and water (250 mL)
4. customThe organic layer was separated
5. washwashed with water (2×250 mL)
6. customseparated
7. customthe solvent removed in vacuo
8. customto afford an orange oil that
9. washGradient elution with 30-50% EtOAc in petrol
10. customafforded a pale orange solid
11. washthat was rinsed with 25% EtOAc in petrol (80 mL)
12. filtrationSolids were collected by filtration
13. customsucked dry

ORD record

ord-7df5b43f492b4df18eb2353ca2229f25

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09018214B2