Hydrochloric Acid → (3,3-Dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-phenyl-amine hydrochloride

HRID 1475355Notes

Reaction equation

HRID 1475355 reaction equation
C(OC([N:8]1[C:16]2[CH:15]=[C:14]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:13]=[CH:12][C:11]=2[C:10]([CH3:25])([CH3:24])[CH2:9]1)=O)(C)(C)C.[ClH:26]>>[ClH:26].[CH3:24][C:10]1([CH3:25])[C:11]2[CH:12]=[N:13][C:14]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:15][C:16]=2[NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86723970HCID 86723970, compound

Product 1

HCID 70981570(3,3-Dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-phenyl-amine hydrochloride

Procedure

3,3-Dimethyl-6-phenylamino-2,3-dihydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (60 mg, 0.18 mmol) was treated with HCl (saturated solution in EtOAc) and stirred for 4 h. The mixture was then evaporated to dryness in vacuo to give a colourless gum which was used without further purification. MS: [M+H]+=240.

Workup

  1. customThe mixture was then evaporated to dryness in vacuo
  2. customto give a colourless gum which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-ab024658de44409eb6b6a16574b08283
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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