Hydrochloric Acid → (3,3-Dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-methyl-phenyl-amine

HRID 1475358Notes

Reaction equation

HRID 1475358 reaction equation
C(OC([N:8]1[C:16]2[CH:15]=[C:14]([N:17]([CH3:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:13]=[CH:12][C:11]=2[C:10]([CH3:26])([CH3:25])[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:25][C:10]1([CH3:26])[C:11]2[CH:12]=[N:13][C:14]([N:17]([CH3:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:15][C:16]=2[NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 867239723,3-Dimethyl-6-(methyl-phenyl-amino)-2,3-dihydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

Product 1

HCID 70981627(3,3-Dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-methyl-phenyl-amine

Procedure

3,3-Dimethyl-6-(methyl-phenyl-amino)-2,3-dihydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (112 mg, 0.32 mmol) was treated with HCl (saturated solution in EtOAc) and stirred for 4 h. The mixture was then evaporated to dryness in vacuo to give a colourless gum which was used directly in the next step without further purification.

Workup

  1. customThe mixture was then evaporated to dryness in vacuo
  2. customto give a colourless gum which
  3. customwas used directly in the next step without further purification

Sources & evidence

ORD record
ord-ce2855d6e37340e58870ea9d2a21c20f
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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