Hydrochloric Acid → 6-(2-Chloro-phenoxy)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride

HRID 1475404Notes

Reaction equation

HRID 1475404 reaction equation
C(OC([N:8]1[C:16]2[CH:15]=[C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[N:13]=[CH:12][C:11]=2[C:10]([CH3:26])([CH3:25])[CH2:9]1)=O)(C)(C)C.Cl>>[ClH:24].[Cl:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[O:17][C:14]1[N:13]=[CH:12][C:11]2[C:10]([CH3:26])([CH3:25])[CH2:9][NH:8][C:16]=2[CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 709805436-(2-Chloro-phenoxy)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

Product 1

HCID 709815546-(2-Chloro-phenoxy)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride

Procedure

6-(2-Chloro-phenoxy)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (143 mg) was treated with HCl (saturated solution in ethyl acetate) and stirred for 4 hours. The mixture was then evaporated to dryness in vacuo to give a colourless solid used directly in the next step without further purification. MS: [M+H]+=275.

Workup

  1. customThe mixture was then evaporated to dryness in vacuo
  2. customto give a colourless solid
  3. customused directly in the next step without further purification

Sources & evidence

ORD record
ord-9915e8e76f674e689becb1760dc98633
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

Loading…