Methyl iodide → HCID 58221581, compound

HRID 1475454Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:19])[CH:4]([C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])[C:5]([O:7][CH3:8])=[O:6].CI.[C:22]([O-])([O-])=O.[K+].[K+]>>[CH3:1][O:2][C:3](=[O:19])[C:4]([C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])([CH3:22])[C:5]([O:7][CH3:8])=[O:6]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 157405961,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate

Product 1

HCID 58221581HCID 58221581, compoundYield 90.5%

Procedure

Following similar methods to those described in Preparation 324 using 2-(4-bromo-2-nitro-phenyl)-malonic acid dimethyl ester (10 g, 30 mmol), MeI (2 mL, 33 mmol) and K2CO3 (4.6 g, 33 mmol) gave the title compound (9.4 g) as a yellow solid. MS: [M+H]+=346.

Sources & evidence

ORD record: ord-dd6e0c60da16483c96ad46b0535d6a1e
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018214B2

Reaction notes

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