HCID 70981283, compound → HCID 70980622, compound

HRID 1475472Notes

Reaction equation

HRID 1475472 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([CH2:14][N:15]2[CH2:19][CH2:18][O:17][C:16]2=[O:20])[N:11]([CH2:21][C:22]([O:24]CC2C=CC=CC=2)=[O:23])[CH2:10][C@H:9]1[CH3:32])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([CH2:14][N:15]2[CH2:19][CH2:18][O:17][C:16]2=[O:20])[N:11]([CH2:21][C:22]([OH:24])=[O:23])[CH2:10][C@H:9]1[CH3:32])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 70981283HCID 70981283, compound

Product 1

HCID 70980622HCID 70980622, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following similar methods to those described in Preparation 12, starting from (2R,5S)-4-benzyloxycarbonylmethyl-2-methyl-5-(2-oxo-oxazolidin-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester (265 mg), and Pd/C (65 mg) gave the title compound (189 mg) as a white solid. MS: [M+H]+=358.

Workup

  1. customthose described in Preparation 12

Sources & evidence

ORD record
ord-e63ce32bb86d44dfb4d113391b51aea2
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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