(S)-3-fluoropyrrolidine → (2R,5S)-4-Benzyl-5-((S)-3-fluoro-pyrrolidin-1-ylmethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	(S)-3-fluoropyrrolidine	HCID 7016277	—
Reactant	tert-butyl (2R,5R)-4-benzyl-5-(chloromethyl)-2-methylpiperazine-1-carboxylate	HCID 86724019	—
Product	(2R,5S)-4-Benzyl-5-((S)-3-fluoro-pyrrolidin-1-ylmethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester	HCID 70981376	—

Reaction Steps

The title compound was prepared following similar methods to those described in Preparation 352 starting from (2R,5R)-4-benzyl-5-chloromethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester (300 mg, 0.88 mmol) and (S)-3-fluoro-pyrrolidine (165 mg, 1.32 mmol). MS: [M+H]+=392.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09018214B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-4a7c7f52da60418b8ad35d8a55447eeb
Source note	uspto-grants-2015_04