反应详情

3-Hydroxy-4-methoxybenzoic acid methyl ester (2.50 g, 13.7 mmol) was dissolved in methanol (20 ml), potassium carbonate (3.72 g, 27.4 mmol) and 2-bromo-1-m-tolyl-ethanone (2.92 g, 13.7 mmol) were added and the mixture was stirred overnight at room temperature. The volatiles were evaporated, the crude material was partitioned between EA and water, the aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was purified by preparative RP HPLC (water/ACN gradient) to yield the title compound.

1. customThe volatiles were evaporated
2. customthe crude material was partitioned between EA and water
3. extractionthe aqueous phase was extracted with EA
4. dry with materialthe combined organic phases were dried over sodium sulfate
5. customevaporated to dryness
6. customThe residue was purified by preparative RP HPLC (water/ACN gradient)