反应详情

To a solution of 3-(4-methoxyphenyl)-3-oxopropanenitrile (5.0 g, 28.5 mmol) in ethanol (100 mL) was added hydrazine hydrate (2.8 mL, 57.1 mmol) at room temperature. The mixture was heated to reflux for 8 h, allowed to cool and concentrated under reduced pressure to about ¼ volume (25 mL). The resulting precipitate was allowed to stir overnight at room temperature, filtered and rinsed with ethanol (2 mL). The title product was dried under vacuum. Yield 4.15 g (77%); LCMS m/z 190.1 (M+H)+, ret. time=1.56 min.

1. temperatureThe mixture was heated
2. temperatureto reflux for 8 h
3. temperatureto cool
4. concentrationconcentrated under reduced pressure to about ¼ volume (25 mL)
5. filtrationfiltered
6. washrinsed with ethanol (2 mL)
7. dry with materialThe title product was dried under vacuum