Sodium hydride → HCID 53241815, compound

HRID 1475963Notes

Reaction equation

HRID 1475963 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[S:7](Cl)(=[O:9])=[O:8].[H-].[Na+].[C:13]([O:16][NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])(=[O:15])[CH3:14]>>[C:13]([O:16][N:17]([S:7]([C:3]1[S:4][CH:5]=[CH:6][C:2]=1[Br:1])(=[O:9])=[O:8])[C:18](=[O:19])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])(=[O:15])[CH3:14]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 10058028(ACETYLOXY)-CARBAMIC ACID TERT-BUTYL ESTERHCID 136755983-Bromothiophene-2-sulfonyl chloride

Product 1

HCID 53241815HCID 53241815, compound

Procedure

tert-Butyl (acetyloxy)[(3-bromothiophen-2-yl)sulfonyl]carbamate (43) is prepared from 3-bromothiophene-2-sulfonyl chloride, sodium hydride and [(tert-butoxy)carbonyl]amino acetate according to Scheme 2. (0.8 g, 35%), 1H NMR (250 MHz, CHLOROFORM-d) δ ppm 7.68 (1H, d, 5.3 Hz), 7.15 (1H, d, 5.2 Hz), 2.30 (3H, s), 1.48 (9H, s).

Sources & evidence

ORD record
ord-9ce6a65144004fcb83a53ad4e08b97ec
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Reaction notes

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