Propionyl chloride → HCID 17825483, compound

HRID 1475964Notes

Reaction equation

[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[C:6]([O:10][C:11]([NH:13][OH:14])=[O:12])([CH3:9])([CH3:8])[CH3:7]>>[C:1]([O:14][NH:13][C:11]([O:10][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:12])(=[O:4])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 97534tert-butyl N-hydroxycarbamate

Product 1

HCID 17825483HCID 17825483, compound

Procedure

[(tert-Butoxy)carbonyl]amino propanoate is prepared from propionyl chloride and N-tert-butoxycarbonyl hydroxylamine according to Scheme 1 described by Carpino et al. J. Am. Chem. Soc. 1959, 955-957. (3.4 g, 48%), 1H NMR (250 MHz, DMSO-d6) δ ppm 10.57 (1H, br. s.), 2.40 (2H, q, 7.5 Hz), 1.40 (9H, s), 1.07 (3H, t, 7.4 Hz).

Sources & evidence

ORD record: ord-512ed0cf4d124a35a142cac98fcadd0c
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018411B2

Reaction notes

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