Phenylacetyl chloride → HCID 86654173, compound

HRID 1475980Notes

Reaction equation

[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:11]([O:15][C:16]([NH:18][OH:19])=[O:17])([CH3:14])([CH3:13])[CH3:12]>>[C:1]1([CH2:7][C:8]([O:19][NH:18][C:16]([O:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:17])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 97534tert-butyl N-hydroxycarbamate

Product 1

HCID 86654173HCID 86654173, compound

Procedure

[(tert-Butoxy)carbonyl]amino 2-phenylacetate is prepared from phenylacetyl chloride and N-tert-butoxycarbonyl hydroxylamine according to Scheme 1 using literature conditions. (8.8 g, 100%), 1H NMR (500 MHz, DMSO-d6) δ ppm 10.66 (1H, br. s.), 7.24-7.38 (5H, m), 3.80 (2H, s), 1.38 (9H, s).

Sources & evidence

ORD record: ord-4721a10814fb4e22b5c936e500f14a2d
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018411B2

Reaction notes

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