Sodium hydride → HCID 53241084, compound

HRID 1475985Notes

Reaction equation

HRID 1475985 reaction equation
[CH3:1][C:2]([CH3:15])([CH3:14])[C:3]([O:5][NH:6][C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])=[O:4].[H-].[Na+].[O:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[CH:20]=[C:19]1[S:27](Cl)(=[O:29])=[O:28]>>[CH3:1][C:2]([CH3:15])([CH3:14])[C:3]([O:5][N:6]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[S:27]([C:19]1[O:18][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[CH:20]=1)(=[O:28])=[O:29])=[O:4]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 300008[(tert-Butoxy)carbonyl]amino 2,2-dimethylpropanoateHCID 27951721-Benzofuran-2-sulfonyl chloride

Product 1

HCID 53241084HCID 53241084, compound

Procedure

N-[(tert-Butoxy)carbonyl]1-benzofuran-2-sulfonamido 2,2-dimethylpropanoate (104) is prepared from [(tert-butoxy)carbonyl]amino 2,2-dimethylpropanoate, sodium hydride and 1-benzofuran-2-sulfonyl chloride according to Scheme 2. δH (250 MHz, DMSO-d6) 8.06 (1H, d, 0.8 Hz), 7.92 (1H, d, 7.3 Hz), 7.81 (1H, dd, 8.5, 0.8 Hz), 7.64 (1H, ddd, 8.5, 7.2, 1.4 Hz), 7.42-7.53 (1H, m), 1.37 (9H, s), 1.28 (9H, s).

Sources & evidence

ORD record
ord-b2dab7caeef0406e877fb0153606d69d
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Reaction notes

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