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tert-butyl N-hydroxycarbamate → [(tert-Butoxy)carbonyl]amino (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-butyl N-hydroxycarbamate | HCID 97534 | — |
| 反応物 | N-(tert-Butoxycarbonyl)-N-methyl-D-alanine | HCID 16211306 | — |
| 生成物 | [(tert-Butoxy)carbonyl]amino (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoate | HCID 86654175 | — |
反応手順
[(tert-Butoxy)carbonyl]amino (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoate is prepared from (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}propanoic acid and N-tert-butoxycarbonyl hydroxylamine according to Scheme 6. The compound exists as rotomers and is reported as such. (0.95 g, 60%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 7.81-7.95 (1H, m), 4.60-5.04 (1H, m), 2.85-2.93 (3H, m), 1.40-1.54 (18H, m), 1.22-1.33 (3H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09018411B2 |
| 出典データセット | uspto-grants-2015_04 |
| ORD ID | ord-1d19402bc6ce4977a4acc8dcaf4165cd |
| 出典メモ | uspto-grants-2015_04 |