Diisopropylamine → (+/-)-Tert-butyl 3-(3-bromo-4-chlorophenyl)-2-cyclobutylpropanoate

Temperature

-20 °C

Under argon, 2.9 ml (20.8 mmol) of diisopropylamine were dissolved in 30 ml of dry THF, and the mixture was cooled to −20° C. 8.3 ml (20.8 mmol) of n-butyllithium solution (2.5 M in hexane) were added dropwise, and the resulting mixture was stirred to −20° C. for 30 min and then cooled to −78° C. At this temperature, a solution of 2.60 g (about 15.3 mmol, crude) of tert-butyl cyclobutylacetate in 10 ml of THF was added. After 4 h of stirring at −78° C., a solution of 3.95 g (13.9 mmol) of 2-bromo-4-(bromomethyl)-1-chlorobenzene in 10 ml of THF was added. The reaction mixture was slowly warmed to RT overnight, and saturated aqueous ammonium chloride solution was then added. The mixture was extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulphate and concentrated under reduced pressure. The solid that remained was triturated with 30 ml of cyclohexane/dichloromethane (1:1) and filtered off. The solid was once more triturated with 10 ml of cyclohexane/dichloromethane (1:1) and again filtered off; this procedure was repeated once more. All filtrates were collected, combined and concentrated under reduced pressure. This residue was then purified further by chromatography on silica gel (mobile phase from pure cyclohexane to cyclohexane/dichloromethane 20:1 to 10:1). This gave 2.24 g of the title compound (43.2% of theory).

1. temperaturecooled to −78° C
2. stirringAfter 4 h of stirring at −78° C.
3. temperatureThe reaction mixture was slowly warmed to RT overnight
4. extractionThe mixture was extracted three times with ethyl acetate
5. dry with materialThe combined organic phases were dried over magnesium sulphate
6. concentrationconcentrated under reduced pressure
7. customThe solid that remained was triturated with 30 ml of cyclohexane/dichloromethane (1:1)
8. filtrationfiltered off
9. customThe solid was once more triturated with 10 ml of cyclohexane/dichloromethane (1:1)
10. filtrationagain filtered off
11. customAll filtrates were collected
12. concentrationconcentrated under reduced pressure
13. customThis residue was then purified further by chromatography on silica gel (mobile phase from pure cyclohexane to cyclohexane/dichloromethane 20:1 to 10:1)

ORD record

ord-bdc45dbf1b3a47eaa81bea6d1da03b04

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09018414B2