Dichloromethane → HCID 178437988, compound

HRID 1476244Notes

Reaction equation

HRID 1476244 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:12]([C:14]3[O:15][C:16]4[C:21]([C:22](=[O:31])[C:23]=3[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH3:13])[N:9]=[C:10](I)[C:3]=12.C([N:39]1[C:47]2[C:42](=[CH:43][CH:44]=[C:45](B3OC(C)(C)C(C)(C)O3)[CH:46]=2)[C:41]([CH2:57][CH3:58])=[N:40]1)(OC(C)(C)C)=O.C(=O)([O-])[O-].[Na+].[Na+].ClCCl>CN(C=O)C.C(O)C.O>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:12]([C:14]3[O:15][C:16]4[C:21]([C:22](=[O:31])[C:23]=3[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH3:13])[N:9]=[C:10]([C:45]3[CH:46]=[C:47]4[C:42]([C:41]([CH2:57][CH3:58])=[N:40][NH:39]4)=[CH:43][CH:44]=3)[C:3]=12

Participants

8

Reactant 4

HCID 6344DichloromethaneHCID 10340Sodium CarbonateHCID 665799322-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-oneHCID 66606521HCID 66606521, compound

Product 1

HCID 178437988HCID 178437988, compoundYield 15%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of Example 57c (0.400 g, 0.758 mmoles) in DMF (4 ml), ethanol (2 ml) and water (2 ml), N-Boc-3-ethyl-6-indazoleboronic acid pinacol ester 103 (0.423 g, 1.137 mmoles) and sodium carbonate (0.241 g, 2.27 mmoles) were added and the system is degassed for 30 min Tetrakistriphenylphosphine Palladium (0.043 g, 0.037 mmoles) was added under nitrogen atmosphere and heated to 80° C. After 12 h, the reaction mixture was celite filtered, concentrated and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by column chromatography with methanol: dichloromethane to afford the title compound as off-white solid (0.060 g, 15% yield). MP: 270-273° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): δ 12.75(s,1H), 8.08(s,1H), 8.05(dd, J=7.9,1.4 Hz, 1H), 7.88(m, 2H), 7.68(d, J=8.4 Hz, 1H), 7.63(s,1H), 7.53(d, J=7.2 Hz, 1H), 7.33(d, J=8.3 Hz, 1H), 7.29(br s, 1H), 7.07(dt, J=8.9,1.4 Hz, 1H), 6.95(br s,2H), 6.07(q, J=6.9 Hz, 1H), 2.98(q, J=7.5 Hz, 2H), 1.92(d, J=7.1 Hz, 3H), 1.34(t, J=7.6 Hz, 3H), Mass: 546.04(M+).

Workup

  1. additionwas added under nitrogen atmosphere
  2. concentrationconcentrated
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over sodium sulphate
  5. concentrationconcentrated under reduced pressure
  6. customThe crude product was purified by column chromatography with methanol

Sources & evidence

ORD record
ord-e18b010dd96d48e290624b24d3de486b
Source dataset
uspto-grants-2015_04
Patent number
US09018375B2

Reaction notes

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