Dichloromethane → HCID 53235393, compound

HRID 1476248Notes

Reaction equation

HRID 1476248 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:12]([C:14]3[O:15][C:16]4[C:21]([C:22](=[O:31])[C:23]=3[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH3:13])[N:9]=[C:10](I)[C:3]=12.[OH:32][CH2:33][C:34]1[S:35][CH:36]=[C:37](B(O)O)[CH:38]=1.C(=O)([O-])[O-].[Na+].[Na+].ClCCl>CN(C=O)C.C(O)C.O>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:12]([C:14]3[O:15][C:16]4[C:21]([C:22](=[O:31])[C:23]=3[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH3:13])[N:9]=[C:10]([C:37]3[CH:38]=[C:34]([CH2:33][OH:32])[S:35][CH:36]=3)[C:3]=12

Participants

8

Reactant 4

HCID 6344DichloromethaneHCID 10340Sodium CarbonateHCID 58314156HCID 58314156, compoundHCID 665799322-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Product 1

HCID 53235393HCID 53235393, compoundYield 14.4%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of Example 57c (0.300 g, 0.568 mmoles) in DMF (4 ml), ethanol (2 ml) and water (2 ml), 2-hydroxymethyl-4-thiopheneboronic acid (0.133 g, 0.853 mmoles) and sodium carbonate (0.180 g, 1.70 mmoles) were added and the system is degassed for 30 min Tetrakistriphenylphosphine Palladium (0.033 g, 0.028 mmoles) was added under nitrogen atmosphere and heated to 80° C. After 12 h, the reaction mixture was celite filtered, concentrated and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by column chromatography with methanol: dichloromethane to afford the title compound as light brown solid (0.042 g, 14% yield). MP: 154-156° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): δ 8.05(s,1H), 8.04(dd, J=7.9,1.4 Hz, 1H), 7.85(m,1H), 7.67(d, J=6.4 Hz, 1H),7.66(s,1H), 7.53(t, J=7.2 Hz, 1H),7.29(br s,1H), 7.20(s,1H), 7.06 (dt, J=8.8,2.1 Hz, 1H),6.98(br s, 2H), 6.02(q, J=6.9 Hz, 1H),5.54(t, J=5.8 Hz, 1H),4.68(d, J=5.7 Hz, 2H), 1.88(d, J=7.0 Hz, 3H). Mass: 514.19(M++1).

Workup

  1. additionwas added under nitrogen atmosphere
  2. concentrationconcentrated
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over sodium sulphate
  5. concentrationconcentrated under reduced pressure
  6. customThe crude product was purified by column chromatography with methanol

Sources & evidence

ORD record
ord-06164593329b4f968491eddf794a44a9
Source dataset
uspto-grants-2015_04
Patent number
US09018375B2

Reaction notes

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