Hydrochloric Acid → HCID 67258727, compound

HRID 1476601Notes

Reaction equation

HRID 1476601 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][N:8]2[C:13]3[CH:14]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[S:16][C:12]=3[C:11](=[O:23])[N:10]([CH:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)[C:9]2=[O:37])[N:6]=1.[ClH:38]>O1CCOCC1>[ClH:38].[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][N:8]2[C:13]3[CH:14]=[C:15]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[S:16][C:12]=3[C:11](=[O:23])[N:10]([CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[C:9]2=[O:37])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67258271HCID 67258271, compound2×

Product 1

HCID 67258727HCID 67258727, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of tert-butyl 4-{1-[(2-methyl-1,3-thiazol-4-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (1.0 g; compound B10) in a solution of hydrogen chloride in 1,4-dioxane (12 ml, 4.0 M) is stirred for 2.5 h at RT. The suspension is filtered and the filter cake is washed with 1,4-dioxane to give the title compound as a solid.

Workup

  1. filtrationThe suspension is filtered
  2. washthe filter cake is washed with 1,4-dioxane

Sources & evidence

ORD record
ord-b9af0863088d40759bb46f57ab743404
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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