Hydrochloric Acid → 6-(2,5-dimethoxyphenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

HRID 1476642Notes

Reaction equation

HRID 1476642 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[S:19][C:18]2[C:17](=[O:20])[N:16]([CH:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[C:15](=[O:34])[N:14]([CH2:35][C:36]3[N:37]=[N:38][N:39]([CH2:41][CH3:42])[N:40]=3)[C:13]=2[CH:12]=1.[ClH:43]>O1CCOCC1>[ClH:43].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[S:19][C:18]2[C:17](=[O:20])[N:16]([CH:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[C:15](=[O:34])[N:14]([CH2:35][C:36]3[N:37]=[N:38][N:39]([CH2:41][CH3:42])[N:40]=3)[C:13]=2[CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67259968tert-butyl 4-[6-(2,5-dimethoxyphenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Product 1

HCID 672584146-(2,5-dimethoxyphenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Tert-butyl 4-[6-(2,5-dimethoxyphenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (331 mg, compound B58) and a solution of hydrogen chloride in 1,4-dioxane (1.4 ml+0.9 ml, 4.0 M) in 1,4 dioxane (20 ml) are reacted according to the procedure described in example B79 to afford the title compound.

Sources & evidence

ORD record
ord-9da7423f3cfe46c18eb4b2e103a8fe4b
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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