Hydrochloric Acid → 1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-(2-fluorophenyl)-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

HRID 1476643Notes

Reaction equation

HRID 1476643 reaction equation
[CH2:1]([N:3]1[N:7]=[N:6][C:5]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[F:24])[S:17][C:13]=3[C:12](=[O:25])[N:11]([CH:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)[C:10]2=[O:39])=[N:4]1)[CH3:2].[ClH:40]>O1CCOCC1>[ClH:40].[CH2:1]([N:3]1[N:7]=[N:6][C:5]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[F:24])[S:17][C:13]=3[C:12](=[O:25])[N:11]([CH:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[C:10]2=[O:39])=[N:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67258330tert-butyl 4-{1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-(2-fluorophenyl)-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate

Product 1

HCID 672587971-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-(2-fluorophenyl)-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Tert-butyl 4-{1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-(2-fluorophenyl)-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (364 mg, compound B59) and a solution of hydrogen chloride in 1,4-dioxane (1.6 ml, 4.0 M) in 1,4 dioxane (10 ml) are reacted according to the procedure described in example B78 to afford the title compound.

Sources & evidence

ORD record
ord-8a7f0dfa534c49be830a4e023976f911
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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