Hydrochloric Acid → HCID 67258065, compound

HRID 1476657Notes

Reaction equation

HRID 1476657 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH2:7][N:8]1[C:13]2[CH:14]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[S:16][C:12]=2[C:11](=[O:23])[N:10]([CH:24]2[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]2)[C:9]1=[O:37].[ClH:38]>O1CCOCC1>[ClH:38].[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH2:7][N:8]1[C:13]2[CH:14]=[C:15]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[S:16][C:12]=2[C:11](=[O:23])[N:10]([CH:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)[C:9]1=[O:37]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67258439HCID 67258439, compound

Product 1

HCID 67258065HCID 67258065, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

According to the procedure described for compound B92 tert-butyl 4-{1-[(3-methylthiophen-2-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (825 mg, compound B74) and a solution of hydrogen chloride in 1,4-dioxane (5.0 ml, 6.8 M) are reacted in 1,4-dioxane (25 ml) to afford the title compound as a solid.

Sources & evidence

ORD record
ord-4f5b80893d5342268768ad46ab207f43
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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