Piperidine → HCID 68616993, compound

HRID 1476735Notes

Reaction equation

HRID 1476735 reaction equation
[CH3:1][O:2][C:3](=[O:35])[CH:4]=[CH:5][C:6]1[CH:34]=[CH:33][C:9]2[N:10]([CH3:32])[C:11]([CH2:13][NH:14]C(OCC3C4C(=CC=CC=4)C4C3=CC=CC=4)=O)=[N:12][C:8]=2[CH:7]=1.N1CCCCC1>ClCCl>[CH3:1][O:2][C:3](=[O:35])[CH:4]=[CH:5][C:6]1[CH:34]=[CH:33][C:9]2[N:10]([CH3:32])[C:11]([CH2:13][NH2:14])=[N:12][C:8]=2[CH:7]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 68615878HCID 68615878, compound

Product 1

HCID 68616993HCID 68616993, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[2-(N-Fmoc-aminomethyl)-1methyl-1H-benzimidazol-5-yl]-acrylic acid methyl ester (43 mg, 0.176 mmol, prepared according to Example 42, step 1-3 by using appropriate starting materials) was dissolved in 10 mL of dichloromethane. The resulting solution was treated with 2.0 mL of piperidine. Removed all the solvent and piperidine under vacuum gave 3-(2-aminomethyl-1-methyl-1H-benzimidazol-5-yl)-acrylic acid methyl ester. MS(m/z): 246 [MH]+.

Workup

  1. customRemoved all the solvent and piperidine under vacuum

Sources & evidence

ORD record
ord-638e1f8b21974b7b92c2e1c74abf1fa9
Source dataset
uspto-grants-2016_08
Patent number
US09402829B2

Reaction notes

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