Hydrochloric Acid → (R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride

HRID 1476749Notes

Reaction equation

HRID 1476749 reaction equation
[ClH:1].C([S@@]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[F:20])=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:20][C:14]1[CH:15]=[CH:16][C:17]([F:19])=[CH:18][C:13]=1[C@H:9]1[CH2:10][CH2:11][CH2:12][NH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89618669HCID 89618669, compound

Product 1

HCID 89618473(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl solution (in Dioxane) (75 mL) was added to stirred solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (15 g, 52.19 mmol) in Dioxane (25 mL) and stirring was continued at 20-35° C. for 4 h. After which the reaction mixture was concentrated under reduced pressure to afford the crude product. The crude product was purified by washing with diethyl ether to afford 7.5 g of the title compound as a white solid.

Workup

  1. concentrationAfter which the reaction mixture was concentrated under reduced pressure
  2. customto afford the crude product
  3. customThe crude product was purified
  4. washby washing with diethyl ether

Sources & evidence

ORD record
ord-3e4850fa9c2442fc89d428e045d0511a
Source dataset
uspto-grants-2016_08
Patent number
US09402833B2

Reaction notes

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