Trifluoroacetic acid → HCID 136597009, compound

HRID 1476848Notes

Reaction equation

HRID 1476848 reaction equation
[CH3:1][N:2]([C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[C:17]([C:25]2[NH:29][C:28](=[O:30])[NH:27][N:26]=2)[N:16]=1)[C@H:3]1[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][N:2]([C@H:3]1[CH2:7][CH2:6][NH:5][CH2:4]1)[C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[C:17]([C:25]2[NH:29][C:28](=[O:30])[NH:27][N:26]=2)[N:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136596959HCID 136596959, compound

Product 1

HCID 136597009HCID 136597009, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To (S)-tert-butyl 3-(methyl(3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)isoquinolin-1-yl)amino)pyrrolidine-1-carboxylate (91 mg, 0.222 mmol) in DCM was added TFA (1.5 mL). After 2 hours the solvent was removed in vacuo to give the title compound, which was used without further purification.

Workup

  1. customAfter 2 hours the solvent was removed in vacuo

Sources & evidence

ORD record
ord-c68c0ad7b00d443888dcbb835240e286
Source dataset
uspto-grants-2016_08
Patent number
US09402841B2

Reaction notes

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