1,4-Dioxane → HCID 136596940, compound

HRID 1476853Notes

Reaction equation

HRID 1476853 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[C:16]([C:24]3[NH:28][C:27](=[O:29])[NH:26][N:25]=3)[N:15]=2)[CH2:9]1)=O)(C)(C)C.O1CCOCC1>Cl>[NH:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[C:16]([C:24]3[NH:28][C:27](=[O:29])[NH:26][N:25]=3)[N:15]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 136596938HCID 136596938, compound

Product 1

HCID 136596940HCID 136596940, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Crude (S)-tert-butyl-3-((3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)isoquinolin-1-yl)oxy)-pyrrolidine-1-carboxylate (1 g, 1.258 mmol) was dissolved in a solution of 4N HCl in dioxane (0.315 mL, 1.258 mmol) and stirred at RT for 30 minutes. The solvent was removed in vacuo and the resulting oil was dried under high vacuum to give the title compound, which used without further purification. ESI-MS m/z [M+H]+ 298.3.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe resulting oil was dried under high vacuum

Sources & evidence

ORD record
ord-59b80f06ce8f4155877fe5e714aaa579
Source dataset
uspto-grants-2016_08
Patent number
US09402841B2

Reaction notes

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