反应详情

To a mixture of (S)-tert-butyl 3-((8-fluoro-3-(hydrazinyl(imino)methyl)isoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate (500 mg, 1.12 mmol) in dioxane (10 mL) was added CDI (362 mg, 2.24 mmol) and the resulting mixture was heated to reflux for 2 hours. The reaction mixture was concentrated in vacuo to give crude product, which was purified by preparative HPLC to give the title compound (220 mg, 47.4%). ESI-MS m/z [M+H-Boc]+ 316.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 2 hours
3. concentrationThe reaction mixture was concentrated in vacuo
4. customto give crude product, which
5. customwas purified by preparative HPLC