反应详情

To a mixture of (S)-tert-butyl 3-((7-chloro-3-(hydrazinyl(imino)methyl)isoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate (350 mg, 0.862 mmol) in dioxane (8 mL) was added CDI (210 mg, 1.293 mmol). The reaction mixture was heated to reflux for 2 hours and was subsequently concentrated in vacuo. The crude product was purified by preparative HPLC to give the title compound (200 mg, 57%).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 2 hours
3. concentrationwas subsequently concentrated in vacuo
4. customThe crude product was purified by preparative HPLC