Hydrogen chloride-ethyl acetate → Hydrochloric Acid

HRID 1476909Notes

Reaction equation

HRID 1476909 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([NH:13][C@H:14]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]1)=[N:10][C:9]([C:26]1[NH:30][C:29](=[O:31])[NH:28][N:27]=1)=[CH:8]2.[ClH:32].CCOC(C)=O>>[ClH:32].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([NH:13][C@H:14]1[CH2:18][CH2:17][NH:16][CH2:15]1)=[N:10][C:9]([C:26]1[NH:30][C:29](=[O:31])[NH:28][N:27]=1)=[CH:8]2

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 136597037HCID 136597037, compound

Product 2

HCID 313Hydrochloric AcidHCID 136596949HCID 136596949, compound

Procedure

A solution of (S)-tert-butyl 3-((8-methoxy-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)isoquinolin-1-yl)amino)pyrrolidine-1-carboxylate (80 mg, 0.187 mmol) in HCl/EtOAc (5 mL) was stirred at RT for 1 hour. The reaction mixture was subsequently concentrated in vacuo to give an HCl salt of the title compound, which was used without further purification (120 mg). ESI-MS m/z [M+H]+ 327.

Workup

  1. concentrationThe reaction mixture was subsequently concentrated in vacuo

Sources & evidence

ORD record
ord-6e58ff76c79045f3ba5ef6d77fa7f8b3
Source dataset
uspto-grants-2016_08
Patent number
US09402841B2

Reaction notes

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