反应详情

A mixture of 2-cyano-4-methylpyridine-1-oxide (4.03 g, 30 mmol) in phosphoryl trichloride (80 mL, 858 mmol) was heated to reflux overnight. The solvent was removed in vacuo. The residue was treated with ice and its pH made basic using saturated NaOH solution at 0° C. The aqueous layer was extracted with DCM (3×). The organic layers were combined, dried over MgSO4, filtered, and evaporated in vacuo to give the title compound (3.7 g, 81%). ESI-MS m/z [M+H]+ 153.6.

1. temperaturewas heated
2. temperatureto reflux overnight
3. customThe solvent was removed in vacuo
4. additionThe residue was treated with ice and its pH
5. customat 0° C
6. extractionThe aqueous layer was extracted with DCM (3×)
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. customevaporated in vacuo