反应详情

温度

160 °C

A mixture of 6-chloro-4-methylpicolinonitrile (3 g, 19.66 mmol) and ethyl hydrazinecarboxylate (8.19 g, 79 mmol) in NMP (6 mL) was heated in a sealed tube at 160° C. overnight. The residue was purified by column chromatography eluting with a gradient of 0-80% EtOAc in heptanes. The product-containing fractions were collected and evaporated in vacuo to give the title compound as a yellow semi-solid (428 mg). ESI-MS m/z [M+H]+211.6.

1. customThe residue was purified by column chromatography
2. washeluting with a gradient of 0-80% EtOAc in heptanes
3. customThe product-containing fractions were collected
4. customevaporated in vacuo