Trifluoroacetic acid → HCID 136596946, compound

HRID 1476921Notes

Reaction equation

HRID 1476921 reaction equation
[CH3:1][C:2]1[C:3]([O:14][C@H:15]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]2)=[N:4][C:5]([C:8]2[NH:12][C:11](=[O:13])[NH:10][N:9]=2)=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][C:11](=[O:13])[NH:10][N:9]=2)=[N:4][C:3]=1[O:14][C@H:15]1[CH2:19][CH2:18][NH:17][CH2:16]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136597021HCID 136597021, compound

Product 1

HCID 136596946HCID 136596946, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-tert-butyl 3-((3-methyl-6-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)oxy)pyrrolidine-1-carboxylate (0.042 g, 0.115 mmol) in DCM (5 mL) was added TFA (1 mL). The reaction mixture was stirred at RT overnight. The solvent was removed in vacuo and the residue was dried under high vacuum to give the title compound, which was used directly to the next step.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-f88d6e5e24df40daa6240cf6f493db03
Source dataset
uspto-grants-2016_08
Patent number
US09402841B2

Reaction notes

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