Hydrochloric Acid → N-[3-(4-fluoro-2-nitrophenoxy)propyl]acetamide

Pyridine (1.5 ml, 18.6 mmol) and acetic anhydride (0.97 g, 10.3 mmol) were added to a dichloromethane solution of 3-(4-fluoro-2-nitrophenoxy)propylamine (2.0 g, 9.33 mmol), while being cooled with ice, and then dichloromethane (4 ml) was further added. The resulting mixture was stirred at room temperature for 15 hours. 2N-hydrochloric acid (9.5 ml) was added to the reaction mixture, and the mixture was stirred. Water was added to the mixture, and the resulting mixture was extracted with dichloromethane. After being washed with a saturated sodium chloride aqueous solution, the organic layer was concentrated under reduced pressure. The residue was then purified by silica gel column chromatography (dichloromethane:methanol=30:1→20:1). The purified product was concentrated under reduced pressure to thereby obtain 2.13 g of oily yellow N-[3-(4-fluoro-2-nitrophenoxy)propyl]acetamide (yield: 89%).

1. temperaturewhile being cooled with ice
2. stirringthe mixture was stirred
3. extractionthe resulting mixture was extracted with dichloromethane
4. washAfter being washed with a saturated sodium chloride aqueous solution
5. concentrationthe organic layer was concentrated under reduced pressure
6. customThe residue was then purified by silica gel column chromatography (dichloromethane:methanol=30:1→20:1)
7. concentrationThe purified product was concentrated under reduced pressure

ORD record

ord-f6f3b0464ce34f1a884cd9f55e722dcd

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09403773B2