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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 147716Generated: October 27, 2026

Tetrahydrofuran → 5-(4-Hydroxy-1-methyl-piperidin-4-yl)-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/147716

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
Reactant1-Methyl-4-piperidoneHCID 74049—
ReactantN-Boc-5-bromoisoindolineHCID 16102683—
ReactantButyllithiumHCID 178418339—
Product5-(4-Hydroxy-1-methyl-piperidin-4-yl)-1,3-dihydroisoindole-2-carboxylic acid tert-butyl esterHCID 66672344—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-5442cd64ba1c4614a9d84308f9dfbe2d
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)