Tetrahydrofuran → 5-(4-Hydroxy-1-methyl-piperidin-4-yl)-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester
Reaction equation
[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH2:14][c:15]2[cH:16][cH:17][c:18]([Br:22])[cH:19][c:20]2[CH2:21]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:23][N:24]1[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]1>>[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH2:14][c:15]2[cH:16][cH:17][c:18]([C:27]3([OH:30])[CH2:26][CH2:25][N:24]([CH3:23])[CH2:29][CH2:28]3)[cH:19][c:20]2[CH2:21]1Participants
5
Sources & evidence
- ORD record
- ord-5442cd64ba1c4614a9d84308f9dfbe2d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
Loading…