反应详情

KOtBu (2.15 g, 19.2 mmol) dissolved in abs. THF (25 mL) was added in drops to a solution of (methoxymethyl)triphenylphosphonium chloride (6.58 g, 19.2 mmol) in abs. THF (25 mL) at 0° C. in argon. The resulting red solution was mixed after 30 min at 0° C. with a solution of 4-dimethylamino-4-(3-fluorophenyl)cyclohexanone (3.0 g, 12.76 mmol) in abs. THF (25 mL) and stirred overnight at RT. The solvent was removed in a vacuum, the residue mixed with 1M sulphuric acid (50 mL) and stirred for 2 h. The precipitate precipitated out during this was separated and the filtrate (pH 1) washed with ether (6×30 mL). The aqueous solution was adjusted to pH 11 with 5N NaOH and extracted with ethyl acetate (3×50 mL). The combined organic phases were dried over Na2SO4 and concentrated to low volume in a vacuum.

1. customat 0° C.
2. customThe solvent was removed in a vacuum
3. additionthe residue mixed with 1M sulphuric acid (50 mL)
4. customThe precipitate precipitated out during
5. customthis was separated
6. washthe filtrate (pH 1) washed with ether (6×30 mL)
7. extractionextracted with ethyl acetate (3×50 mL)
8. dry with materialThe combined organic phases were dried over Na2SO4
9. concentrationconcentrated to low volume in a vacuum