反应详情

The title compound from step 1 (160 mg, 0.387 mmol) was dissolved in abs. THF (15 mL) and mixed with LiAlH4 (29 mg, 0.775 mmol) in argon. The batch was boiled for 7 h with reflux and then cooled to room temperature. THF (5 mL) and H2O (5 mL) were added to the batch with ice cooling and subsequently stirred for 30 min. The batch was filtered over a fritted glass filter with diatomaceous earth and subsequently rinsed with dichloromethane (50 mL). The combined filtrates were concentrated to low volume in vacuum.

1. temperaturewith reflux
2. filtrationThe batch was filtered over a fritted glass
3. filtrationfilter with diatomaceous earth
4. washsubsequently rinsed with dichloromethane (50 mL)
5. concentrationThe combined filtrates were concentrated to low volume in vacuum