HCID 86595549, compound → HCID 86595548, compound

HRID 1477388Notes

Reaction equation

HRID 1477388 reaction equation
[CH2:1]1[C:3]2([CH2:8][CH:7]([C:9]([O-:11])=[O:10])[CH2:6][NH:5][CH2:4]2)[CH2:2]1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:2]1[C:3]2([CH2:8][CH:7]([C:9]([OH:11])=[O:10])[CH2:6][NH:5][CH2:4]2)[CH2:1]1

Participants

4

Reactant 1

HCID 86595549HCID 86595549, compound

Product 1

HCID 86595548HCID 86595548, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

The above product of tert-butyl(6S,7S)-6-((4-phenyl)piperazin-1-yl)carbonyl)-5-azaspiro(2,5)octane-7-carboxylate was stirred in 8 mL of 50% TFA in methylene chloride solution (v/v) for 4 hours. After removal of solvent, the residue was dried under high vacuum overnight to give (6S,7S)-6-((4-phenyl)piperazin-1-yl)carbonyl)-5-azaspiro(2,5)octane-7-carboxylic acid. LC-MS: m/z 344.1 (M+H)+.

Workup

  1. customAfter removal of solvent
  2. customthe residue was dried under high vacuum overnight

Sources & evidence

ORD record
ord-40801ee6c1354cbab601f646e675cdb9
Source dataset
uspto-grants-2016_08
Patent number
US09403775B2

Reaction notes

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