HCID 58993709, compound → HCID 58993743, compound

HRID 1477484Notes

Reaction equation

HRID 1477484 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:15]1[CH2:20][CH2:19][C:18]([CH3:22])([CH3:21])[CH2:17][CH:16]=1.[K+].[C:24]([C:26]1[N:27]=[C:28]([C:39]([O-])=[O:40])[N:29]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:30]=1)#[N:25]>>[CH3:21][C:18]1([CH3:22])[CH2:19][CH2:20][C:15]([C:3]2[CH:4]=[C:5]([CH:8]3[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]3)[CH:6]=[CH:7][C:2]=2[NH:1][C:39]([C:28]2[N:29]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:30]=[C:26]([C:24]#[N:25])[N:27]=2)=[O:40])=[CH:16][CH2:17]1

Participants

3

Reactant 2

HCID 58993709HCID 58993709, compoundHCID 67188357potassium 4-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Product 1

HCID 58993743HCID 58993743, compound

Procedure

The title compound was prepared from 4-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-cyclohexanone (as prepared in the previous step) and 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylate potassium salt (as prepared in Example 1, step (d)) according to the procedure in Example 1, step (f). Mass spectrum (APCI, m/z): Calcd. for C31H42N4O3Si, 547.3 (M+H). found 547.0.

Sources & evidence

ORD record
ord-be640523ed764c878a63cd16863e0300
Source dataset
uspto-grants-2016_08
Patent number
US09403804B2

Reaction notes

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