1-Hydroxy-2-naphthoic acid → HCID 71715111, compound

HRID 1477543Notes

Reaction equation

HRID 1477543 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([NH2:11])[CH2:8][N:7]1[CH2:12][CH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:5])[CH3:2].[OH:18][C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[C:29](O)=[O:30]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([NH:11][C:29]([C:20]2[CH:21]=[CH:22][C:23]3[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:19]=2[OH:18])=[O:30])[CH2:8][N:7]1[CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 89776130HCID 89776130, compound

Product 1

HCID 71715111HCID 71715111, compound

Procedure

(2S,4S)-1-Cyclopentylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylic acid ethyl ester was prepared from (2S,4S)-4-amino-1-cyclopentylmethyl-pyrrolidine-2-carboxylic acid ethyl ester and 1-hydroxy-naphthalene-2-carboxylic acid in an analogous manner to example 1. MS calcd. for C24H31N2O4 [(M+H)+] 411.0, obsd. 411.2.

Sources & evidence

ORD record
ord-05fa76d52e974ea5b3298643677b777d
Source dataset
uspto-grants-2016_08
Patent number
US09403805B2

Reaction notes

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