1-Hydroxy-2-naphthoic acid → HCID 71715116, compound

HRID 1477544Notes

Reaction equation

HRID 1477544 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([NH2:11])[CH2:8][N:7]1[CH2:12][CH:13]1[CH2:16][CH2:15][CH2:14]1)=[O:5])[CH3:2].[OH:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1[C:28](O)=[O:29]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([NH:11][C:28]([C:19]2[CH:20]=[CH:21][C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:18]=2[OH:17])=[O:29])[CH2:8][N:7]1[CH2:12][CH:13]1[CH2:16][CH2:15][CH2:14]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 89776148HCID 89776148, compound

Product 1

HCID 71715116HCID 71715116, compound

Procedure

(2S,4S)-1-Cyclobutylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylic acid ethyl ester was prepared from (2S,4S)-4-amino-1-cyclobutylmethyl-pyrrolidine-2-carboxylic acid ethyl ester and 1-hydroxy-naphthalene-2-carboxylic acid in an analogous manner to example 1. MS calcd. for C23H29N2O4[(M+H)+] 397.0, obsd. 397.2.

Sources & evidence

ORD record
ord-e997524218bb458d9809af3b0f670c83
Source dataset
uspto-grants-2016_08
Patent number
US09403805B2

Reaction notes

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