1-Hydroxy-2-naphthoic acid → HCID 71715113, compound

HRID 1477546Notes

Reaction equation

HRID 1477546 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([NH2:11])[CH2:8][N:7]1[C:12]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])=[O:5])[CH3:2].[OH:20][C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1[C:31](O)=[O:32]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([NH:11][C:31]([C:22]2[CH:23]=[CH:24][C:25]3[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:21]=2[OH:20])=[O:32])[CH2:8][N:7]1[C:12]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 89776168HCID 89776168, compound

Product 1

HCID 71715113HCID 71715113, compound

Procedure

(2S,4S)-1-Cyclohexanecarbonyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]pyrrolidine-2-carboxylic acid ethyl ester was prepared (2S,4S)-4-amino-1-cyclohexanecarbonyl-pyrrolidine-2-carboxylic acid ethyl ester and 1-hydroxy-naphthalene-2-carboxylic acid in an analogous manner to example 1. MS calcd. for C25H31N2O5 [(M+H)+] 439.0, obsd. 439.4.

Sources & evidence

ORD record
ord-278b9ecd60144c0b95c654d3110155e5
Source dataset
uspto-grants-2016_08
Patent number
US09403805B2

Reaction notes

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