1-Hydroxy-2-naphthoic acid → HCID 71715912, compound

HRID 1477559Notes

Reaction equation

HRID 1477559 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][C@H:9]([NH2:11])[CH2:8][CH2:7][N:6]1[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:4].[OH:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[C:30](O)=[O:31]>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][C@H:9]([NH:11][C:30]([C:21]2[CH:22]=[CH:23][C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:20]=2[OH:19])=[O:31])[CH2:8][CH2:7][N:6]1[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:4]

Participants

3

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 89776152HCID 89776152, compound

Product 1

HCID 71715912HCID 71715912, compound

Procedure

(2S,4R)-1-Cyclohexylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-piperidine-2-carboxylic acid methyl ester was prepared from (2S,4R)-4-amino-1-cyclohexylmethyl-piperidine-2-carboxylic acid methyl ester and 1-hydroxy-naphthalene-2-carboxylic acid in an analogous manner to example 1. MS calcd. for C25H33N2O4 [(M+H)+] 425, obsd. 425.

Sources & evidence

ORD record
ord-17e9c1fab53c4ebfa7268a7f3032295c
Source dataset
uspto-grants-2016_08
Patent number
US09403805B2

Reaction notes

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