Sodium Hydroxide → HCID 136954683, compound

HRID 1477568Notes

Reaction equation

HRID 1477568 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[N:3]=1.[OH-:22].[Na+]>>[Cl:1][C:2]1[NH:7][C:6](=[O:22])[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[N:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 11045887HCID 11045887, compound

Product 1

HCID 136954683HCID 136954683, compoundYield 101.1%

Procedure

tert-Butyl 4-(4,6-dichloro-1,3,5-triazin-2-yl)piperazine-1-carboxylate (14.9 g, 44.5 mmol) synthesized in Reference Synthesis Example 5 and 1 M sodium hydroxide aqueous solution (111 mL, 111 mmol) were used to obtain the title compound (14.2 g, quantitative) by synthesis in a similar manner to Reference Synthesis Example 2.

Sources & evidence

ORD record
ord-b252e6ea1154415c822d757d05cd6361
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

Loading…