HCID 84681537, compound → HCID 117839585, compound

HRID 1477620Notes

Reaction equation

HRID 1477620 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][C:6]=2[CH:7]=1>[Pd].C(O)C>[F:15][C:2]([F:1])([F:14])[CH:3]1[CH2:7][C:6]2[CH:8]=[C:9]([CH2:12][OH:13])[CH:10]=[CH:11][C:5]=2[O:4]1

Participants

4

Reactant 1

HCID 84681537HCID 84681537, compound

Product 1

HCID 117839585HCID 117839585, compoundYield 52.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To an ethanol solution (1.0 mL) of [2-(trifluoromethyl)benzofuran-5-yl]methanol (30.0 mg, 0.139 mmol) synthesized in Reference Synthesis Example 96, palladium-activated carbon (15.0 mg) was added and the resultant solution was stirred under hydrogen atmosphere at room temperature for 30 hours. After completion of the reaction, the reaction solution was filtered with Celite and the filtrate was concentrated under reduced pressure to obtain a crude product of the title compound (15.9 mg).

Workup

  1. additionwas added
  2. customAfter completion of the reaction
  3. filtrationthe reaction solution was filtered with Celite
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0953faf15d1343e8af781d7d288a7ea4
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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