反应详情

To a tetrahydrofuran solution (1.0 mL) of (R)-5-(aminomethyl)-1-(4-fluorophenyl)pyrrolidin-2-one (50.0 mg, 0.240 mmol) synthesized in Reference Synthesis Example 216, borane-tetrahydrofuran complex (8.5% tetrahydrofuran solution) (0.760 mL, 0.720 mmol) was added and the resultant mixture was stirred at room temperature for 1 hour 30 minutes. Thereafter, the borane-tetrahydrofuran complex (1.0 mL) was further added and the resultant mixture was stirred at 70° C. for 1 day. After completion of the reaction, methanol was added to the reaction solution and the resultant mixture was stirred at 70° C. for 3 hours, followed by concentrating the reaction solution under reduced pressure to obtain a crude product of the title compound.

1. additionwas added
2. additionThereafter, the borane-tetrahydrofuran complex (1.0 mL) was further added
3. additionwas added to the reaction solution
4. concentrationby concentrating the reaction solution under reduced pressure