Hydrazine hydrate (1:1) → HCID 65174758, compound

HRID 1477648Notes

Reaction equation

HRID 1477648 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:12][CH2:11][CH:10]([N:13]3C(=O)C4C(=CC=CC=4)C3=O)[CH:9]=2)=[CH:4][CH:3]=1.O.NN>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 117839480HCID 117839480, compound

Product 1

HCID 65174758HCID 65174758, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

To an ethanol solution (0.50 mL) of 2-[3-(4-fluorophenyl)cyclopent-2-en-1-yl]isoindoline-1,3-dione (10.0 mg, 0.0325 mmol) synthesized in Reference Synthesis Example 222, hydrazine monohydrate (3.16 μL, 0.0651 mmol) was added and the resultant mixture was stirred at room temperature for 1 day. Further, the reaction solution was stirred at 70° C. for 6 hours and then stirred at room temperature for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure and was washed with chloroform to obtain a crude product of the title compound.

Workup

  1. additionwas added
  2. stirringstirred at room temperature for 1 day
  3. customAfter completion of the reaction
  4. concentrationthe reaction solution was concentrated under reduced pressure
  5. washwas washed with chloroform

Sources & evidence

ORD record
ord-d2c52beac9e44e0ba74998669e09e862
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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